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The ever-involved George Clooney is among the stars who’ll appear on the fund-raising Stand Up to Cancer event, airing on VH1 (among channels) on Friday, September 10 at 8/7c. Full details of the expanding lineup are in the press release below:

The extraordinary lineup of actors, musicians, athletes and journalists participating in the Stand Up To Cancer (SU2C) prime-time roadblock television fund-raising event (September 10, 2010, at 8PM EST & PST / 7PM CT) continues to grow. The following supporters have now joined the broadcast: Elizabeth Banks, Kathy Bates, Sir Richard Branson, Michael Chiklis, George Clooney, Baron Davis, Emily Deschanel, Bill Hader, Dorothy Hamill, Anne Heche, Cheryl Hines, Randy Jackson, George Karl, Dr. Jon Lapook, Rob Lowe, Jane Lynch, Marlee Matlin, Shareen Mitchell, Olivia Munn, Lisa Niemi, Kelly Osbourne, Gwyneth Paltrow, Matt Passmore, Will Smith, Sam Trammell, Denzel Washington, Aaron Yoo and Renée Zellweger.

Musical guests scheduled to perform include: Billie Joe Armstrong of Green Day, Neil Diamond, The Edge, Delta Goodrem, Herbie Hancock, Kris Kristofferson, Lady Antebellum, Leona Lewis, Orianthi and Ann Wilson and Nancy Wilson of Heart. These artists join previously announced performers including Natasha Bedingfield, Martina McBride, Aaron Neville, Dave Stewart and Stevie Wonder.

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Queen Latifah, Stevie Wonder and Natasha Bedingfield will be among those participating in a musical collaboration set to air during the previously announced Stand Up to Cancer fund-raising event, which is set to air on VH1 (among many stations) on Sept. 10 at 8/7c. Additionally, celebs like Reese Witherspoon, Seth Rogen and Christina Applegate will be participating in the event. Current talent lineup and more details are in the press release below…

An extraordinary line-up of actors, musicians, athletes and journalists have banded together for Stand Up To Cancer (SU2C), the groundbreaking initiative aimed at raising funds to accelerate innovative cancer research bringing new therapies to patients quickly that will saves lives now. Stand Up To Cancer will return to primetime TV on September 10, 2010, at 8PM EST & PST / 7PM CT. The one-hour fundraising event will be simulcast live and commercial-free on ABC, CBS, FOX, NBC, Bio, Discovery Health, E!, G4, HBO, HBO Latino, MLB Network, mun2, Showtime, Smithsonian Channel, The Style Network, TV One, and VH1.

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On Friday, September 10 at 8/7c, VH1 will be among the stations simulcasting the hour-long fund-raising event Stand Up to Cancer. Above is a PSA that will run during the broadcast called Change the Odds. It features the likes of Zac Efron, Dakota Fanning, Vanessa Hudgens, Kristen Bell and Jon Heder, and was co-directed by (500) Days of Summer filmmaker Marc Webb. You don’t have to wait till September to donate, though — you can do it from the YouTube page of the video embedded above or at the official site of Stand Up to Cancer.